![]() Bottom line is Seattle needs more answers up front if the guys currently on the roster can't stay healthy. McGill of the 49ers makes sense as depth at nose tackle should he not make San Francisco's roster. Seattle could look for quality, experienced depth during final roster cuts to add to this group, or perhaps even make a trade. Specifically, with Brown and Oluwatimi, Seattle has two good options at the center position for the first time since Max Unger anchored the offensive line. The Seahawks have the most talent and depth along the offensive line since Carroll's Super Bowl teams. The key question regarding Bobo is: Do the Seahawks envision him performing on special teams during the regular season? Dee Eskridge will miss the first six games for violating the NFL's personal conduct policy. While I still believe the Seahawks could sneak the undrafted UCLA product onto the practice squad because of his slow 40-yard time, they could look to keep him on the active roster because of the injury to Smith-Njigba. ![]() The Jake Bobo experience has been impressive and entertaining during exhibition play. Fant, whom Seattle received as part of the trade with the Broncos for Wilson, is in the final year of his rookie deal. So keeping a fourth tight end like Tyler Mabry could be a consideration. The Seahawks used two tight end sets 29.5% of the time last season, according to Next Gen Stats, No. Recent addition SaRodorick Thompson has performed well and could be worth keeping around on the practice squad. ![]() Carroll wants to run the ball, so building depth for the long haul at this position group is important. ![]() Walker, Charbonnet and McIntosh all have dealt with injuries during training camp. ![]()
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![]() Membership supports the production of new books, educational games, and movies. Choose from a variety of topics, such as vowels, sight words, R-control, and more, and track your progress with the Starfall Learn to Read app. Kids can learn reading, writing, math, counting, ABCs, addition, subtraction. Starfall’s low-cost membership program expands the free content to include additional animated songs, mathematics activities, and reading. Starfall Education offers a sequential phonics method to help children learn to read with fun and interactive games, movies, and ebooks. Inspire a lifetime of learning with our educational app for kids ages 2-8. Cons: No tools for assessment or tracking. It is widely used in schools and homeschools. Pros: Covers key phonics basics and melds auditory, visual, and tactile learning activities. Choose from games, books, and ebooks for different levels of phonics skills and topics. Its emphasis on phonemic awareness, systematic sequential phonics, and common sight words in conjunction with audiovisual interactivity is especially effective for teaching emergent readers, children of all ages with special needs or learning difficulties, as well as ELL (ESL) students. Starfall has been teaching children to read with phonics for well over a decade. Starfall offers a variety of fun and engaging activities to help children learn to read with a proven sequential phonics method. Starfall activities are research-based and align with state learning objectives for English language arts and mathematics. Due to the engaging content that “feels like play,” Starfall serves as an educational alternative to other entertainment choices for children. The program emphasizes exploration, play, and positive reinforcement-encouraging children to become confident and intrinsically motivated. Learn to Read from the website is now a FREE app The Starfall Learn to Read FREE app is made possible by the member supporters of. Print and color The Nutcracker Activity Guide. Since then it has expanded to include standards in language arts and mathematics for preschool through fifth grade and above. Unlock the magic of reading and phonics with the new Super Whys Comic Book AdventuresLearn More. ![]() Starfall was developed in the classroom by teachers and opened in August 2002 as a free public service to teach children to read. He was motivated to create a learning platform with untimed, multisensory interactive games that allow children to see, hear, and touch as they learn. Our low-cost membership program expands the free. It is widely used in schools that serve children with special needs and learning difficulties. ![]() Stephen Schutz, who had difficulty learning to read as a child due to dyslexia. Starfall is an educational alternative to other entertainment choices for children and is especially effective for special education, homeschooling, and English language development (ELD, ELL, ESL). At Starfall, children have fun while they learn ![]() ![]() 'Experiment with a mix of complementary and contrasting colors to create visual interest incorporating lively patterns and textures to add depth. By embracing dynamic colors, arranging furniture strategically, incorporating statement pieces, playing with lighting, and bringing the outdoors inside, you can create a space that not only looks vibrant but also radiates positive energy,' says Niko Rasides, Design director of Nicholas Anthony. 'Transforming a flat and uninspiring space into an energetic and inviting haven requires thoughtful consideration of color, furniture placement, and overall design. To keep everyone a little more connected and to evoke a sense of cohesiveness within the space too, inject color, greenery, and more light where you can. No matter how big or small your overall party size may be, guests will still naturally form groups. ![]() Keep spaces connected using color, nature, and lighting After all, there is no better time to discuss the veins of a blue cheese than over the holidays. 'Clearing and repositioning furniture to accommodate food stations ensures that refreshments are easily accessible to guests, facilitating a smooth flow for dining and socializing.' Decide how guests will be served, or serve themselves, and pave the way to these spots so that visitors will naturally gravitate to them, and have space to linger comfortably. 'Practical considerations, like establishing designated buffet or bar areas, are also a big part of the spatial planning,' highlights Davis. As hosts, we want to make it clear where this magic will happen. 'Set up a place for a buffet and bar area where people can serve themselves and make sure there is plenty of room to make it easy to get to food and drinks,' adds Alzaga. 'If you have a plethora of tiny, tippy drinks tables (guilty!), take these out of the main pathway as you are guaranteed a spilled cocktail otherwise.'Īs well as conversation, when guests come over for the holidays, they are (politely) expecting gorgeously crafted cocktails and a feast. 'Work to eliminate any chance of a stubbed toe or cracked shin with the furniture, and any potential bottlenecks of people,' adds Adams. Though they may be decorative throughout the rest of the year, if there is a chance they are more of a hindrance to the space when it is at capacity, it needs a holiday relocation. You need to recognize when things are needed, and when they are not. 'I try to make the room look as functional as possible without destroying the beautiful balance I have worked so hard to achieve.' 'I often remove the dining chairs to both reduce furniture clutter and make room to circulate around a buffet on the table. Taking away furniture that doesn't serve and that will hinder flow is key: 'Whenever I host I anticipate the need for easy circulation around a home, rearranging furniture as needed,' says interior designer Glenn Gissler. Focus on the flow of your guests around the furniture, and from room to room,' says Interior designer Bethany Adams. 'It often becomes necessary to rearrange furniture to accommodate hosting duties, especially during the holiday season when any extra space is taken up by temporary decorations. ![]() Consider how many you are hosting, if people will arrive at different times, where guests might flock to, and how to free up pathways in a visually appealing manner. ![]() (Image credit: Future | SARAH KAYE REPRESENTATION LTD | Photography by Polly Wreford, styling by Sally Denning)Īs easy as it is to think that pushing everything out to the side, and revealing floor space will solve elbow bumps and canapés on the floor, there is a right way to go about it. ![]() ![]() ![]() In May, the Metropolitan Museum in New York stages the first exhibition devoted to Van Gogh’s fascination with the “flamelike evergreens”, reuniting The Starry Night and Wheat Field with Cypresses, among international loans.On your plate in this chic Parisian brasserie, you will find modern, responsible, creative cuisine as part of a sustainability-oriented approach, created with local, seasonal products, showcased by Thierry Marx. Something similar happens in Wheatfield with Cypresses, where Van Gogh left a gap between a big and small cypress, and both seem to lean into each other like the tower’s legs.” Its base is bulked up with a smaller tree, which makes its shape more pyramidal and closer to that of the tower. “The cypress tree was the first part to be painted. Hall writes: “Van Gogh’s Starry Night is nature’s and history’s response to Eiffel’s bombastic shuddering metal monster that sought to surpass the Egyptians … The obeliscal cypress dominates Saint-Rémy and its church spire in much the same way that the 300-metre Eiffel Tower dominates Paris. Newspapers and journals, including Le Monde Illustré, which Van Gogh read in Saint-Rémy, carried “wonderstruck” illustrated reports of the opening. In 1887, a Paris newspaper published a letter signed by leading artists and writers condemning it as a “dizzily ridiculous tower”, and by the time Van Gogh left Paris in February 1888 its construction had risen above the skyline, reaching its first platform.Īn 1888 official guide proclaimed that whereas the pyramids were built by slaves for tyrants, this monument was “a manifestation of pure science, august art and liberty of labour”. He observes that in 1886, when Van Gogh had just arrived in Paris, a competition to build the monument was launched and won by Gustave Eiffel’s open-lattice wrought-iron feat of engineering, and that its planning and preparation were constantly in the news. His research will appear in the April issue of the scholarly Burlington Magazine. ![]() Hall, whose previous books include The Artist’s Studio: A Cultural History, is a research professor at Southampton University. Van Gogh idealised ancient Egypt, and he thought the cypress tree was as beautiful and well-proportioned as an obelisk.” Hall said: “The tower was bombastically marketed as a symbol of French technological prowess, and even more impressive than the pyramids. It’s beautiful as regards lines and proportions, like an Egyptian obelisk.” In June 1889, Van Gogh wrote to his brother Theo: “The cypresses still preoccupy me, I’d like to do something with them like the canvases of the sunflowers because it astonishes me that no one has yet done them as I see them. ![]() Starry Night is a rural and cosmic counterpart to the light show that marked the opening of the exhibition.” Hall said: “For Van Gogh, the cypress tree is a natural alternative to the Eiffel Tower, the centrepiece of the exhibition. He argues that the artist began this series in June 1889, shortly after the Paris monument was unveiled as the star attraction of the International Exposition, whose opening was accompanied by a spectacular late-night show of pyrotechnics, electric light and explosions that he says are repeated in the “pyrotechnical music of the stars, sky and clouds” of Van Gogh’s painting. ![]() ![]() ![]() ![]() This figure shows how information regarding contour intervals is shown on the map, as taken from one of the US Army’s topographic map series 2201 (Dar Es Salaam 1:2,000,000 topographic maps) When supplementary contours are used, their interval is also indicated on the map. Information regarding the contour interval used in the map is usually shown in the marginal information on that given map. In other words, contour interval is the difference in height between any two successive contours on map. This vertical spacing between the contour lines is what is known as contour interval or vertical interval. These lines are drawn in such a way that they have to be evenly spaced vertically. However, for simplification, only the lines for certain elevations are drawn on the map. This figure shows how contour lines are shown on mapĬontour lines can be drawn for relatively any elevation. Contour lines lie perpendicular to streams and rivers.Usually, closely spaced contour lines indicate a steep slope while contour lines far apart indicate gentle slope. The spacing or gap between the contour lines represents the degree of slope.However, the only exception for this is ‘overhanging cliffs’ where many contour lines merge to form one contour line. This is because it is impossible to have a point on earth’s surface that can be at two or more different elevations above sea level at the same time. Contour lines never cross or intersect each other.Usually these numbers represent the exact elevation of land above sea level for all points along that line. They are numbered in either feet or meters, above sea level.They connect points of equal elevations above mean sea level.Generally, the contour lines have the following characteristics: Contouring is the most common method of showing relief on topographic maps because it has the ability to show all five (5) aspects of relief (shape, orientation, size, elevation and slope) on the map. The act of using contour lines in order to represent the relief of an area on the map is known as contouring. Contour lines are the lines drawn on the map connecting all points on the earth’s surface with equal elevations above a fixed datum line (usually the mean sea level). ![]() ![]() First of all, place the insertion pointer where you need to type the Spade symbol ( ♠).Also, ensure that your Num Lock key is turned on.īelow is a breakdown of the Spade Symbol shortcut for Mac: You must use the numeric keypad to type the alt code. For Windows, use the Alt Code method by pressing down the key whilst typing the Spade symbol alt code which is 6. You can also explore the table below for different variation of the Spade symbols alongside their alt code shortcuts: Using the Spade Symbol Shortcut (Mac and Windows)įor Mac users, the keyboard shortcut for the Spade Symbol is Option + 2660. This is how you may type this symbol in Word using the Alt Code method. Release the Alt key after typing the Spade Sign Alt code to insert the Symbol into your document.On some laptops, there’s a hidden numeric keypad which you can enable by pressing Fn+NmLk on the keyboard. If you are using a laptop without the numeric keypad, this method may not work for you. Whilst holding on to the Alt key, press the Spade Symbol’s alt code ( 6).Press and hold one of the Alt keys on your keyboard.Place your insertion pointer where you need the Spade Symbol text.Below is a break-down of the steps you can take to type the Spade Sign on your Windows PC: block ) ASCII code 24 = CAN ( Cancel ) ASCII code 25 = EM ( End of medium ) ASCII code 26 = SUB ( Substitute ) ASCII code 27 = ESC ( Escape ) ASCII code 28 = FS ( File separator ) ASCII code 29 = GS ( Group separator ) ASCII code 30 = RS ( Record separator ) ASCII code 31 = US ( Unit separator ) ASCII code 127 = DEL ( Delete ) Printable ASCII characters :ĪSCII code 32 = space ( Space ) ASCII code 33 = ! ( Exclamation mark ) ASCII code 34 = " ( Double quotes Quotation mark speech marks ) ASCII code 35 = # ( Number sign ) ASCII code 36 = $ ( Dollar sign ) ASCII code 37 = % ( Percent sign ) ASCII code 38 = & ( Ampersand ) ASCII code 39 = ' ( Single quote or Apostrophe ) ASCII code 40 = ( ( round brackets or parentheses, opening round bracket ) ASCII code 41 = ) ( parentheses or round brackets, closing parentheses ) ASCII code 42 = * ( Asterisk ) ASCII code 43 = + ( Plus sign ) ASCII code 44 =, ( Comma ) ASCII code 45 = - ( Hyphen, minus sign ) ASCII code 46 =. The operating system of this model, the "MS-DOS" also used this extended ASCII code.Īlmost all computer systems today use the ASCII code to represent characters and texts.ĪSCII code 00 = NULL ( Null character ) ASCII code 01 = SOH ( Start of Header ) ASCII code 02 = STX ( Start of Text ) ASCII code 03 = ETX ( End of Text, hearts card suit ) ASCII code 04 = EOT ( End of Transmission, diamonds card suit ) ASCII code 05 = ENQ ( Enquiry, clubs card suit ) ASCII code 06 = ACK ( Acknowledgement, spade card suit ) ASCII code 07 = BEL ( Bell ) ASCII code 08 = BS ( Backspace ) ASCII code 09 = HT ( Horizontal Tab ) ASCII code 10 = LF ( Line feed ) ASCII code 11 = VT ( Vertical Tab, male symbol, symbol for Mars ) ASCII code 12 = FF ( Form feed, female symbol, symbol for Venus ) ASCII code 13 = CR ( Carriage return ) ASCII code 14 = SO ( Shift Out ) ASCII code 15 = SI ( Shift In ) ASCII code 16 = DLE ( Data link escape ) ASCII code 17 = DC1 ( Device control 1 ) ASCII code 18 = DC2 ( Device control 2 ) ASCII code 19 = DC3 ( Device control 3 ) ASCII code 20 = DC4 ( Device control 4 ) ASCII code 21 = NAK ( NAK Negative-acknowledge ) ASCII code 22 = SYN ( Synchronous idle ) ASCII code 23 = ETB ( End of trans. IBM includes support for this code page in the hardware of its model 5150, known as "IBM-PC", considered the first personal computer. In this way was added the ASCII characters ranging from 128 to 255. Also 128 characters were added, with new symbols, signs, graphics and latin letters, all punctuation signs and characters needed to write texts in other languages, such as Spanish. ![]() ![]() ![]() In 1981, IBM developed an extension of 8-bit ASCII code, called "code page 437", in this version were replaced some obsolete control characters for graphic characters. So with this set of only 128 characters was published in 1967 as standard, containing all you need to write in English language. This code arises from reorder and expand the set of symbols and characters already used in telegraphy at that time by the Bell company.Īt first only included capital letters and numbers, but in 1967 was added the lowercase letters and some control characters, forming what is known as US-ASCII, ie the characters 0 through 127. The American Standard Code for Information Interchange, or ASCII code, was created in 1963 by the "American Standards Association" Committee or "ASA", the agency changed its name in 1969 by "American National Standards Institute" or "ANSI" as it is known since. ![]() ![]() ![]() Here are a few you may want to keep in mind when planning and budgeting for relocating your piano. Other factors may contribute to the cost your moving company will take into account when charging either an hourly or flat rate. Some piano movers set a minimum of three hours of labor-which is an estimated average amount of time it takes for a professional to do a relatively easy move. Do your research and consider the average rates based on your location. You might be able to get a better deal, as long as your moving company is quick and effective. ![]() charge a base rate of about $50, and then add additional charges depending on the circumstances of the move.Īn hourly rate is helpful if you expect the move to be straightforward and time efficient. Any company may base its pricing on basic factors such as piano type, distance of travel and the complexity of maneuvers requiring extra tools or materials.įor the most part, however, a flat rate will be fairly consistent (based on the company’s preset moving costs) and therefore leaves you with less guesswork. Most piano moving companies will provide a flat rate, allowing you to budget up front for your move. Related: Best Long Distance Moving Companies Hourly Rates vs. If you require an international or overseas move, you can expect a flat rate from $3,000 to $5,000. We recommend you compare the costs of companies based at either end of the move-origin and destination-to see who offers better long distance rates. A rural town’s moving company will charge a much lower rate than a company in a large city, especially if a simple local move is required. Depending on where you live and where your moving company is based, general prices will vary. Long Distanceĭistance and location are some of the most common deciding factors in piano moving service fees. Moving a grand piano long distance can be closer to $2,000 or even as high as $5,000 or more. These behemoths generally can cost anywhere from $200 to $1,500 to move locally. Grand pianos are much heavier and well, grand, so they require more materials and equipment. If you are moving an upright piano, the moving cost could be anywhere from $150 to $1,000, depending on where you’re based and whether the move is local or long distance. In general, upright pianos cost less to move simply because they are less hefty and awkward, requiring fewer resources and less time. While we work hard to provide accurate and up to date information that we think you will find relevant, Forbes Home does not and cannot guarantee that any information provided is complete and makes no representations or warranties in connection thereto, nor to the accuracy or applicability thereof. The compensation we receive from advertisers does not influence the recommendations or advice our editorial team provides in our articles or otherwise impact any of the editorial content on Forbes Home. Second, we also include links to advertisers’ offers in some of our articles these “affiliate links” may generate income for our site when you click on them. This site does not include all companies or products available within the market. ![]() The compensation we receive for those placements affects how and where advertisers’ offers appear on the site. First, we provide paid placements to advertisers to present their offers. This compensation comes from two main sources. To help support our reporting work, and to continue our ability to provide this content for free to our readers, we receive compensation from the companies that advertise on the Forbes Home site. The Forbes Home editorial team is independent and objective. ![]() ![]() ![]() It is used but in excellent condition with only typical minor scratches and has always been well maintained. Our big gripe with the spec though, is the KS dropper post – it still pulls up when you lift the bike onto an uplift trailer or workstand, and we can’t believe KS hasn’t sorted this problem because it’s been on-going for several years now.Condition: Good - Used, Mechanically SoundĢ019 forest green Commencal Meta TR 29 British Edition is an awesome bike and was voted bike of the year in the UK in 2019. And while the Schwalbe tyres are meaty – offering some cushioning – the compound is pretty hard, so they tend to ping around on roots and don’t encourage you to crank the bike over in turns. Still, the SRAM shifting is precise and it’s also quiet compared to the Shimano drivetrain on the Radon Slide Trail 9.0. This means you only get the two-piston SRAM Level T disc brakes, a bottom-end GX and NX Eagle drivetrain and the Addix (grey) Performance Schwalbe Magic Mary and Hans Dampf tyres. ComponentsĬompared to all the juicy stuff on the British Edition, the Meta TR 29 Ride gets pretty basic kit. In fact, we’re really scratching our heads as to why Commençal fitted the Revelation RC over a Yari, because that fork has a softer initial touch to the damping and is way more in keeping with the overall attitude of this bike. ![]() If anything, the RockShox fork encourages you to sit back more, rather than lean into it, which just highlights how readily the Meta gives up its 130mm rear travel. Which is a real shame, because last year we’d compensate for the lack of rear travel on the Meta by riding more on the fork, but this isn’t something we could do as readily on the entry-level bike. Obviously there’s a difference in stiffness and steering precision between the Revelation RC and the Fox 36 Factory on the top-end bike, but what’s most marked is the reduction in performance of the Motion Control damper in the RockShox – it’s just nothing like as sophisticated as the Grip2 unit in the Fox fork and feels harsh on square-edge hits. Travel remains the same at 150mm, so the geometry of the bike doesn’t change, even with the switch in suspension components. The 2020 Meta TR 29 Ride gets a RockShox Revelation RC suspension fork. Wide enough for us to also catch our calf muscles and knee pads on the top of the seatstays and rocker link. On the 2019 bike, several testers clipped their heels on the swingarm, and the rear end on the 2020 version is every bit as wide. It’s also worth noting that while the flagship model is available in four sizes, the Meta TR 29 Ride is limited to three, the small size being eliminated from the line. And it’s worth noting that even though it’s the cheapest bike on test by quite some margin, it’s only 500g heavier than the full-carbon YT Jeffsy 29 CF Comp. It still uses the same triple-butted aluminium frameset with 130mm travel as the top-end bike, but gets a more affordable build kit. This year, with all of the changes to the format of our Trail Bike of the Year test, we have had to shuffle down Commençal’s pecking order to the entry-level Meta TR 29 Ride. Last year, we tested Commençal’s top-end Meta Trail 29 British Edition. Note: price is €2,699 and UK price may vary according to exchange rate. Trail Bike of the Year in association with AlpinestarsĬommençal puts a lot of effort into the look and style of its bikes and the Commencal Meta TR 29 has a great presence on the trail. ![]() ![]() ![]() Since the company caters only to bulk buyers, most of its customers are wholesalers from all over the world, with the United States, Europe and Australia as the biggest markets. Considering the interest of new customers and new product lines we expect to see an increase in sales volume to around 400 containers in 2014.Ĭlose to 100% of the value of the company’s output is exported, with less than 1% of its output sold to the domestic market. The average sales for the last decennium stand at 300 to 350 containers yearly. ![]() It also contributes a considerable amount of income to the municipality of Angono and generates dollar earnings for the country.įrom a low of 209 containers in 1997, shipments peaked at 474 containers in 2004. It is operating under Philippine laws and regulations. The company has complied and complies with all government regulatory business permits and licenses. Please find an overview of the owners/officers below: Ownership is composed of five (5) major stockholders. For example, Yab Design produced custom-made products (usually for advertising purposes) for Coca Cola, Levi’s, several computer game developers, ING Bank, Philippine government, Cruzcampo Beer, Motorola, Samsung and Gillette. These items will be developed based on the specific requirements of a certain customer. Halloween, pirates, Indians, medieval, butlers, waiters, bakers, sports figures, famous artists, singers, actors, politicians, etc.).īesides the own products of Yab Design, which are available for all customers, Yab Design also performs special projects and develops of custom-made items. Yab Designs product range mainly exists out of: Yab Design is a manufacturer of handcrafted (polyester) resin and fiberglass items and statues, mainly used for decoration and advertising purposes. By transferring to here, it is easier to find factory workers with the required level of expertise. The main reason for moving to Angono was that Angono is a city famous for well skilled artists. Four (4) hectares are covered warehouses which include administrative offices. Together they paved the way for establishing a strong position for Yab Design in the global market.Īfter Laguna, the new management decided to transfer to Angono, Rizal where it rents an area of 11 hectares for its production site. Yab Design is owned and managed by the owner himself, together with a team of Dutch and Filipino nationals. Jakob acquired the company in 1998 when sales were at $2 million and in a span of 6 years, sales doubled to over $4 million. This was under the ownership of Daniel van der Hulst, the elder brother of the now existing owner of Yab Design, Mr. The Company was established when the resin and fiberglass reproduction and decoration industry was bustling in the early 90’s. The reason for Yab Design is ability to survive in this competitive market is because Yab Design has a special niche in the industry – excellent designs and craftsmanship, concentration on relatively larger product types, flexibility of continued generation of new products and designs and a wide variety of products. The Philippines has also embraced the Western culture much more than any other country in Asia and English is widely spoken.Īt present, only a few of these, including Yab Design, have been able to survive in what is now a very competitive global market. Manufacturing companies in resin and fiberglass industry in the Philippines are often owned and managed by foreign nationals (Dutch, German, Spanish, British, French, etc. who ventured into the Philippines not only because of very competitive labour costs, but more specifically for the skilled craftsmanship of the local labour force, an essential element in the resin reproduction and decoration industry. ![]() ![]() These datasets were combined to produce the PanopTILs dataset, available at /view/panoptils. The Breast Cancer Semantic Segmentation dataset is available at /PathologyDataScience/BCSS, and the NuCLS dataset is available at /view/nucls. TCGA clinical data and WSIs are publicly available at. We provide this to facilitate reproducibility and to act as a resource for the scientific community. Supplementary Table 27 contains our calculated histomic feature values, HiPS scores and subscores, and related data for the TCGA cohort. In conclusion, HiPS is a robustly validated biomarker to support pathologists and improve patient prognosis. ![]() This was largely driven by stromal and immune features. HiPS consistently outperformed pathologists in predicting survival outcomes, independent of tumor–node–metastasis stage and pertinent variables. ![]() It was developed using a population-level cohort from the Cancer Prevention Study-II and validated using data from three independent cohorts, including the Prostate, Lung, Colorectal, and Ovarian Cancer trial, Cancer Prevention Study-3, and The Cancer Genome Atlas. HiPS uses deep learning to accurately map cellular and tissue structures to measure epithelial, stromal, immune, and spatial interaction features. Here we present the Histomic Prognostic Signature (HiPS), a comprehensive, interpretable scoring of the survival risk incurred by breast tumor microenvironment morphology. ![]() Pathologists grade the microscopic appearance of breast tissue using the Nottingham criteria, which are qualitative and do not account for noncancerous elements within the tumor microenvironment. Breast cancer is a heterogeneous disease with variable survival outcomes. ![]() |
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